@conference {41533,
	title = {Regulating milk fat synthesis: potential on-farm applications of basic science},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {65},
	year = {2005},
	month = {Jan},
	pages = {33-39},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	address = {Christchurch},
	abstract = {  This review covers results from numerous trials evaluating conjugated linoleic acid (CLA) effects on milk fat  synthesis and its potential as an on-farm management tool to improve dairy cow performance. Supplemental CLA reduces  milk fat synthesis in numerous animal models, and in grazing dairy cows can improve energy balance as well as increase  milk and milk protein yield.  Mammary lipid metabolism effects are thus far specific to  trans-10,  cis-12 CLA, and we  demonstrated trans-10, cis-12 CLA reduces mRNA expression of enzymes required for de novo fatty acid synthesis, fatty  acid uptake and intracellular transport, and triglyceride formation. The amount of CLA required to reduce milk fat synthesis  in lactating cows has little or no effect on circulating basal bioenergetic metabolites and hormones or stimulated responses  to homeostatic signals.  We hypothesized CLA can be utilized to stimulate milk fat depression when milk synthesis and  other physiological processes are limited by energy availability, as is the case in early lactation, during heat stress and  occasionally in pasture based dairying. Our research focuses on identifying the mechanisms of action and potential use of  CLA as an on-farm management tool to increase farm profit via increased milk production, improved reproduction and  decreased metabolic disorders.},
	issn = {1176-5283},
	author = {Baumgard LH and Kay JK and Moore CE and Roche JR and Vanbaale MJ and Rhoads RP}
}
