@conference {40307,
	title = {The effect of three allowances of red clover on Red deer fawn growth and liveweight change in lactating hinds},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {51},
	year = {1991},
	month = {Jan},
	pages = {185-188},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {The binding of monoclonal antibodies (MAbs) of predetermined  specificity to growth hormone (GH) can result in significant enhancement  of the biological activity of the hormone in vivo. The  topographic region on GH associated with the enhancement phenomenon has  been localised to two proximate sites on adjacent loop regions by  extensive peptide synthesis (sequences: 35-53 and 134-154). The  application of these observations of GH and (ii) increased production  parameters following administration of particular antibodies. The  latter aspect has now been demonstrated in a number of animal models by  the passive vaccination of animals with purified anti-peptide antisera  or monoclonal antibodies. Production parameters affected in such  experiments include growth rate, fat metabolism, diabetogenic activity  and lactation in ewes. At the present time, it has been shown that  peptide sequence 134-154 will elicit up to 80\% high titre, immuno-  positive responders in sheep. Monitoring the growth rate and other  production parameters of lambs vaccinated with sequence 134-154  indicates improved growth and total protein characteristics. These  observations, in conjunction with the development of methodologies for  effective autoimmunization of animals, may provide a basis for the  design of peptide vaccines to improve animals, may provide a basis for  the design of peptide vaccines to improve animal production.  },
	issn = {1176-5283},
	author = {Niezen JH and Barry TN and Hodgson J and Wilson PR and Holmes CW}
}
