@conference {40539,
	title = {Plasma concentrations of progesterone and luteinizing hormone during CIDR device insertion and the oestrous cycle of fallow deer (Dama dama)},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {53},
	year = {1993},
	month = {Jan},
	pages = {417-422},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {Quantitative two-dimensional polyacrylamide gel electrophoresis has  been used to search for variation among liver proteins in flocks of sheep  which had been selected for either resistance or susceptibility to sporidesmin-  induced liver damage. The goal was identification of proteins whose DNA  sequences might be used to select animals for resistance to facial eczema.  The quantitative gel techniques were used because of their ability to detect  variability among many proteins in a single tissue sample. Differences in  relative proportion were tested for 62 proteins among 5 ewes from each of the  resistant and susceptible flocks. There were 7 proteins which showed  statistically significant differences (P<0.05) between the flocks. When an  analysis was made of changes in the relative proportions of proteins 2 days  after experimental challenge of resistant flock ewes (n=8) with sporidesmin,  0.13 mg per kg body weight, 25 of 79 liver proteins showed significant change  (P<0.05). This included partial loss of a 25 kDa, pI 5.7, protein which was  also three times more abundant in undosed susceptible than undosed resistant  females. These results are discussed in terms of the possible relationships  between protein variation and the magnitude of toxic tissue damage.  },
	issn = {1176-5283},
	author = {Morrow CJ and Asher GW and Smith JF and Veldhuizen FA}
}
