@conference {40576,
	title = {Mammary involution in ewes: Changes in milk plasminogen and plasmin},
	booktitle = {Proceedings of the New Zealand Society of Animal Production},
	volume = {54},
	year = {1994},
	month = {Jan},
	pages = {107-110},
	publisher = {New Zealand Society of Animal Production},
	organization = {New Zealand Society of Animal Production},
	abstract = {Multiparous Border Leicester x Romney ewes were weaned early (day 35  
of lactation), milked to empty the mammary gland and again milked 18 h later  
(day 0 of experiment) to establish baseline milk yields and concentrations in  
milk of the proteolytic enzyme plasmin and its zymogen plasminogen.  They  
were then divided into 3 groups to be milked 3 (n=5), 8 (n=6) or 15 (n=5) days  
after the day 0 milking to determine changes in concentrations and yields of  
plasmin and plasminogen in mammary gland secretions during involution.   
Yields (mean{\textpm}SE) on days 0 (groups 1 + 2 + 3), 3 (group 1), 8 (group 2) and 15  
(group 3) were: secretion (g), 785{\textpm}31.2 v. 598{\textpm}94.8 v. 478{\textpm}86.8 v. 51{\textpm}66.6;  
plasminogen (mg), 7.8{\textpm}2.2 v. 78.7{\textpm}11.1 v. 22.4{\textpm}4.6 v. 3.9{\textpm}2.1; and plasmin  
(ug), 11.5{\textpm}2.38 v. 148.5{\textpm}8.00 v. 51.6{\textpm}7.92 v. 4.9{\textpm}2.32.  Corresponding  
concentrations in the secretions were (ug/ml): plasminogen, 0.01{\textpm}0.002 v.  
0.15{\textpm}0.027 v. 0.046{\textpm}0.005 v. 0.061{\textpm}0.007; and plasmin, 0.015{\textpm}0.006 v.  
0.275{\textpm}0.027 v. 0.118{\textpm}0.011 v. 0.083{\textpm}0.009.  There was a linear decline in the  
volume of secretions from day 0 to day 15.  In contrast there was a transient  
increase (15 fold) in plasminogen and plasmin yields by 3 days after milking.   
These data suggest that any role of plasmin in mammary gland involution is  
likely to be limited to the first week after early weaning. },
	issn = {1176-5283},
	author = {MacKenzie DDS and Cottam YH and Knutson RJ and McCutcheon SN}
}
